Cannabis for Parkinson's Disease

The brain has a rich expression of cannabinoid receptors in various sites, such as the G-protein coupled receptor GPR6 within the basal ganglia (a key part of the brain affected by Parkinson’s). Studies investigating the oral intake of CBD oil (and smoking cannabis) in the treatment of Parkinsonian symptoms have observed generally positive results.

One observational study reported rapid alleviation of Parkinsonian symptoms (including bradykinesia and tremor) upon cannabis smoke inhalation (CBD + THC) in around 79% of patients (out of 28). In another study, 56% of a small cohort of patients showed improvement in mood and sleep issues.