Cannabis Treatments for Neuralgia

Cannabinoid-based drugs act on the human endocannabinoid system, a network of CB1, CB2 and other receptors distributed throughout the body. Oral THC formulations show variable absorption and undergo extensive first-pass hepatic metabolism resulting in decreased concentration peak plasma THC compared to inhalation and a longer delay (~120 min) to reach peak concentration. Oral formulations may be useful for patients requiring symptomatic relief over a longer period.